Op-cvre160028 555..567
نویسندگان
چکیده
Institute of Medical Pathology, Universit a Cattolica, Rome 00168, Italy; Institute of Cell Biology and Neurobiology, National Research Council, Rome 00143, Italy; Institute of Human Physiology, Medical School, Universit a Cattolica, Rome 00168, Italy; Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino, Milan 20138, Italy; Department of Cardiovascular Medicine, Universit a Cattolica, Rome 00168, Italy; Department of Pediatric Cardiology and Cardiac Surgery, Bambino Ges u Children’s Hospital IRCCS, Rome, Italy; San Raffaele Pisana Scientific Institute for Research, Hospitalization and Health Care, 00163 Rome, Italy; and Goethe University, Internal Medicine Clinic III, Frankfurt am Main 60590, Germany
منابع مشابه
Learning from Corrupted Binary Labels via Class- Probability Estimation Classification with Corrupted Binary Labels
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متن کاملEssential domains for ribonucleoprotein complex formation required for retrotransposition of telomere-specific non-long terminal repeat retrotransposon SART1.
Non-long terminal repeat (LTR) retrotransposons are major components of the higher eukaryotic genome. Most of them have two open reading frames (ORFs): ORF2 encodes mainly the endonuclease and reverse transcriptase domains, but the functional features of ORF1 remain largely unknown. We used telomere-specific non-LTR retrotransposon SART1 in Bombyx mori and clarified essential roles of the ORF1 ...
متن کاملDetection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.
Soluble HLA-DR401 or -DR404 tetramers containing a peptide corresponding to an immunodominant epitope from human GAD65 were used to analyze peripheral blood T-cells of newly diagnosed type 1 diabetic patients and at-risk subjects. Peripheral blood mononuclear cells were expanded on antigen-presenting cells presenting GAD65 peptide and subsequently activated with specific plate-bound class II-pe...
متن کاملPharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function.
The aim of this work was to evaluate the effects of BM-567 (N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP receptors of human washed platelets has been determined. In this test, BM-567 showed a high affinity (IC(50): 1.1+/-0.1nM) for the...
متن کاملPeroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in Apc mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
A large body of studies has suggested that peroxisome proliferator-activated receptor ; (PPAR;) ligands, such as thiazolidinedione, are potent candidates for chemopreventive agents. MCC-555 is a PPAR;/A dual agonist and has been shown previously to induce apoptosis in vitro; however, the molecular mechanisms by which MCC-555 affects antitumorigenesis in vivo are poorly understood. In this study...
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